Analysis of the effect of childhood stress on the expression of serotonin system genes in the hippocampus and cortex in adult male rats
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Abstract
Reflects an interaction between genetic susceptibility and environmental factors such as stress are likely underlying neurobiology of major depression. Various factors have been proposed in anxiety behaviors caused by childhood stress, but the role of 5HT-3 and 5HT-2c receptors in its occurrence has been less investigated. Excessive expression of related genes in the brain is associated with the formation of anxiety behaviors (1-3). In this research, six pregnant rats were used. After giving birth, their babies experience separation stress from their mothers, called Maternal Neonatal Separation or childhood stress. This article aims to investigate the effect of childhood stress on 5HT-3 and 5HT-2c gene expression in the hippocampus and cortex and the possible effects of exercise on anxiety behaviors and 5HT-3 and 5HT-2c gene expression in the hippocampus and cortex in male rats. This article showed that voluntary exercise during adolescence can reduce the of these gene expression in the brain and has a protective role against stress.
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Heisler, L. K., et al. "Serotonin 5-HT2C receptors regulate anxiety-like behavior." Genes, Brain and Behavior 6.5 (2007): 491-496.
Martin, James R., Theresa M. Ballard, and Guy A. Higgins. "Influence of the 5-HT2C receptor antagonist, SB-242084, in tests of anxiety." Pharmacology Biochemistry and Behavior 71.4 (2002): 615-625.
Jones, B. J., et al. "The potential anxiolytic activity of GR38032F, a 5-HT3-receptor antagonist." British journal of pharmacology 93.4 (1988): 985-993.
Nitschke, Jack B., Wendy Heller, and Gregory A. Miller. "Anxiety, stress, and cortical brain function." The neuropsychology of emotion (2000): 298-319.
Vyas, Ajai, et al. "Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons." The Journal of Neuroscience 22.15 (2002): 6810-6818.
Anand KS, Dhikav V. Hippocampus in health and disease: An overview. Ann Indian Acad Neurol. 2012 Oct;15(4):239-46. doi: 10.4103/0972-2327.104323. PMID: 23349586; PMCID: PMC3548359.
Esfanjani, M., Faress, F., & Esfanjani, M. (2022). Analyzing the issues of asymmetry in the strength of fencers bodies and the effectiveness of combining Aerobics with Fencing on their muscles by a new sport AeroFencing, 2(2), 12-21. https://doi.org/10.47577/teh.v2i2.7259
Smith KE, Pollak SD. Early life stress and development: potential mechanisms for adverse outcomes. J Neurodev Disord. 2020 Dec 16;12(1):34. doi: 10.1186/s11689-020-09337-y. PMID: 33327939; PMCID: PMC7745388.
O'Mahony, Siobhain M., et al. "Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses." Biological psychiatry 65.3 (2009): 263-267.
Mann, J. John. "Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior." Neuropsychopharmacology 21 (1999): 99S-105S.
Azmitia, E. C., and P. M. Whitaker-Azmitia. "Awakening the sleeping giant: anatomy and plasticity of the brain serotonergic system." The Journal of clinical psychiatry 52 (1991): 4-16.
Gordon, Joshua A., and Rene Hen. "The serotonergic system and anxiety." Neuromolecular medicine 5.1 (2004): 27-40.
Leonard, B. E. "The HPA and immune axes in stress: the involvement of the serotonergic system." European Psychiatry 20 (2005): S302-S306.
Chaouloff, Francis. "Physiopharmacological interactions between stress hormones and central serotonergic systems." Brain Research Reviews 18.1 (1993): 1-32.
Caspi, Avshalom, et al. "Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene." Science 301.5631 (2003): 386-389.
Kimura, Atsuko, et al. "Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity." European Journal of Neuroscience 30.2 (2009): 299-306.
Costall, Brenda, and Robert J. Naylor. "Anxiolytic Potential of 5-HT3 Receptor Antagonists." Pharmacology & toxicology 70.3 (1992): 157-162.
Heisler, L. K., et al. "Serotonin 5-HT2C receptors regulate anxiety-like behavior." Genes, Brain and Behavior 6.5 (2007): 491-496.
Martin, James R., Theresa M. Ballard, and Guy A. Higgins. "Influence of the 5-HT2C receptor antagonist, SB-242084, in tests of anxiety." Pharmacology Biochemistry and Behavior 71.4 (2002): 615-625.
Slifirski G, Krol M, Turlo J. 5-HT Receptors and the Development of New Antidepressants. Int J Mol Sci. 2021 Aug 20;22(16):9015. doi: 10.3390/ijms22169015. PMID: 34445721; PMCID: PMC8396477.
Bhatia, Nitish, et al. "Animal models of stress." International Journal of Pharmaceutical Sciences and Research 2.5 (2011): 1147.
Blanchard, Robert J., Christina R. McKittrick, and D. Caroline Blanchard. "Animal models of social stress: effects on behavior and brain neurochemical systems." Physiology & behavior 73.3 (2001): 261-271.
Dishman, Rod K. "Brain monoamines, exercise, and behavioral stress: animal models." Medicine & Science in Sports & Exercise (1997).
Wipfli, Bradley M., Chad D. Rethorst, and Daniel M. Landers. "The anxiolytic effects of exercise: A meta-analysis of randomized trials and dose--response analysis." Journal of sport & exercise psychology 30.4 (2008): 392.
Sheri R. Colberg, Ronald J. Sigal, Jane E. Yardley, Michael C. Riddell, David W. Dunstan, Paddy C. Dempsey, Edward S. Horton, Kristin Castorino, Deborah F. Tate; Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association. Diabetes Care 1 November 2016; 39 (11): 2065-2079. https://doi.org/10.2337/dc16-1728
-Esfanjani
M.,Safaris. & Faress, F (2021). Backstepping Nonlinear Control by using Sliding Mode Observer for controlling Blood Sugar, Technion BioChemMed Vol. 2, Issue 1 pp.119-130 (2021) ISSN: 2734-7990
Bird SR, Hawley JA. Update on the effects of physical activity on insulin sensitivity in humans. BMJ Open Sport Exerc Med. 2017 Mar 1;2(1):e000143. doi: 10.1136/bmjsem-2016-000143. PMID: 28879026; PMCID: PMC5569266
Salmon, Peter. "Effects of physical exercise on anxiety, depression, and sensitivity to stress: a unifying theory." Clinical psychology review 21.1 (2001): 33-61.
Radak, Zsolt, Hae Young Chung, and Sataro Goto. "Exercise and hormesis: oxidative stress-related adaptation for successful aging." Biogerontology 6.1 (2005): 71-75.
Purves D, Augustine GJ, Fitzpatrick D, et al., editors. Neuroscience. 2nd edition. Sunderland (MA): Sinauer Associates; 2001. The Biogenic Amines. Available from: https://www.ncbi.nlm.nih.gov/books/NBK11035/
Lesch, Klaus-Peter, et al. "Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region." Science 274.5292 (1996): 1527.
Richardson, B. P., et al. "Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs." Nature 316.6024 (1985): 126.
Peroutka, Stephen J., and Solomon H. Snyder. "Multiple serotonin receptors: differential binding of [3H] 5-hydroxytryptamine,[3H] lysergic acid diethylamide and [3H] spiroperidol." Molecular pharmacology 16.3 (1979): 687-699.
Reynolds, Gavin P., Zhi-Jun Zhang, and Xiao-Bin Zhang. "Association of antipsychotic druginduced weight gain with a 5-HT2C receptor gene polymorphism." The Lancet 359.9323 (2002): 2086-2087.
Martin, J. R., et al. "5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential." Journal of Pharmacology and Experimental Therapeutics 286.2 (1998): 913-924.
Reynolds, Gavin P., Lucy A. Templeman, and Zhi Jun Zhang. "The role of 5-HT2C receptor polymorphisms in the pharmacogenetics of antipsychotic drug treatment." Progress in Neuro-Psychopharmacology and Biological Psychiatry 29.6 (2005): 1021-1028.
Maricq, Andres V., et al. "Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel." Science 254.5030 (1991): 432-437.
de Boer-Dennert, M., et al. "Patient perceptions of the side-effects of chemotherapy: the influence of 5HT3 antagonists." British journal of cancer 76.8 (1997): 1055.
Barr, Christina S., et al. "Serotonin Transporter Gene Variation is Associated with Alcohol Sensitivity in Rhesus Macaques Exposed to Early-Life Stress." Alcoholism: Clinical and Experimental Research 27.5 (2003): 812-817.
Veenema, Alexa H., et al. "Effects of early life stress on adult male aggression and hypothalamic vasopressin and serotonin." European Journal of Neuroscience 24.6 (2006): 1711-1720.
Erickson, Kirk I., Destiny L. Miller, and Kathryn A. Roecklein. "The aging hippocampus interactions between exercise, depression, and BDNF." The Neuroscientist 18.1 (2012): 82-97.
M.A. Sheridan, K.A. McLaughlin Dimensions of early experience and neural development: deprivation and threat Trends Cogn Sci, 18 (2014), pp. 580-585.
T.Z. Baram, E.P. Davis, A. Obenaus, C.A. Sandman, S.L. Small, A. Solodkin, H. Sternw Fragmentation and unpredictability of early-life experience in mental disorders Am J Psychiatry, 169 (2012), pp. 907-915.
B. Seay, E. Hansen, H.F. Harlow Mother-infant separation in monkeys J Child Psychol Psychiatry, 3 (1962), pp. 123-132.
Salmon, Peter. "Effects of physical exercise on anxiety, depression, and sensitivity to stress: a unifying theory." Clinical psychology review 21.1 (2001): 33-61.
M. Rincon-Cortes, R.M. Sullivan Early life trauma and attachment: immediate and enduring effects on neurobehavioral and stress axis development Front Endocrinol, 5 (2014)
M. Kundakovic, F.A. Champagne Early-life experience, epigenetics, and the developing brain
Neuropsychopharmacology, 40 (2015), pp. 141-153
J. Molet, P.M. Maras, S. Avishai-Eliner, T.Z. Baram Naturalistic rodent models of chronic early-life stress Dev Psychobiol, 56 (2014), pp. 1675-1688
M. Nishi, N. Horii-Hayashi, T. Sasagawa Effects of early life adverse experiences on the brain: implications from maternal separation models in rodents Front Neurosci, 8 (2014), p. 166
J L Bolton, J Molet , A Ivy, T Z Baram. New insights into early-life stress and behavioral outcomes, Current Opinion in Behavioral Sciences 2017, 14:133-139
Tada, T. Miyazaki, K. Takemoto, K. Takase, S. Jitsuki, W. Nakajima, M. Koide, N. Yamamoto, K. Komiya, K. Suyama, et al.Neonatal isolation augments social dominance by altering actin dynamics in the medial prefrontal cortex Proc Natl Acad Sci U S A, 113 (2016), pp. E7097-E7105
O'Mahony, Siobhain M., et al. "Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses." Biological psychiatry 65.3 (2009): 263-267.
Nugent, Nicole R., et al. "Gene-environment interactions: early life stress and risk for depressive and anxiety disorders." Psychopharmacology 214.1 (2011): 175-196.
Pehek, Elizabeth A., et al. "Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress-and drug-induced dopamine release in the rat medial prefrontal cortex." Neuropsychopharmacology 31.2 (2006): 265-277.
McKittrick, Christina R., et al. "Serotonin receptor binding in a colony model of chronic social stress." Biological psychiatry 37.6 (1995): 383-393.
Thierry, Anne-Marie, Marton Fekete, and Jacques Glowinski. "Effects of stress on the metabolism of noradrenaline, dopamine and serotonin (5HT) in the central nervous system of the rat (II) modifications of serotonin metabolism." European journal of pharmacology 4.4 (1968): 384-389.
Caspi, Avshalom, et al. "Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene." Science 301.5631 (2003): 386-389.
Martinowich, Keri, and Bai Lu. "Interaction between BDNF and serotonin: role in mood disorders." Neuropsychopharmacology 33.1 (2008): 73-83.
File, Sandra E., and Amanda L. Johnston. "Lack of effects of 5HT3 receptor antagonists in the social interaction and elevated plus-maze tests of anxiety in the rat." Psychopharmacology 99.2 (1989): 248-251.
Martin, James R., Theresa M. Ballard, and Guy A. Higgins. "Influence of the 5-HT2C receptor antagonist, SB-242084, in tests of anxiety." Pharmacology Biochemistry and Behavior 71.4 (2002): 615-625.
Bagdy, Gyorgy, et al. "Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635." International Journal of Neuropsychopharmacology 4.4 (2001): 399-408.
Amiri, Shayan, et al. "Tropisetron attenuated the anxiogenic effects of social isolation by modulating nitrergic system and mitochondrial function." Biochimica et Biophysica Acta (BBA)-General Subjects 1850.12 (2015): 2464-2475.